Ai design for novel therapeutic peptides

Ai design for novel therapeutic peptides

OPENING UP THE DRUG EXPLORATION SPACE

Pepticom designs novel peptide drug candidates,
utilizing unique biocomputational AI software, to optimize the discovery process, accelerate time to market and reduce development risks and costs

 

 

WE ARE ABOUT UNLOCKING THE HIDDEN POTENTIAL OF PEPTIDE DRUGS

Our mission is to advance 21st century medicine by improving access to novel peptide therapeutics. We harness the power of AI to design the best peptide drugs possible by expanding the exploration process to uncharted chemical space.

MORE OPTIONS. FASTER.

Optimizing drug discovery means shifting the weight of the discovery effort in-silico, to allow an accelerated search of the entire realm of possible solutions.
Pepticom is introducing “Swarm Intelligence 2.0”, in which various bots are able to sense, interact and coordinate a collective intelligence with the addition of evolutionary mechanism of bot-selection.
Utilizing AI-driven reinforcement learning, search algorithms, smart grids and scoring functions allows Pepticom to discover better binding peptides at each learning iteration.

AI learning helps implement the right conclusions towards finding the optimal peptides for target binding.

3 FORMS OF CYCLIZATION

Backbone N to C cyclization, Disulfide cyclization, Thioether cyclization

FLEXIBLE LENGTH

2-25 amino acid (linear peptides)
5-20 amino acid (cyclic peptides)

CHARACTERIZATION

Control of specific chemical attributes and risk factors

BINDING SITE

Binding site and mode information for accurate modifications and optimization

CHEMICAL DIVERSITY

More non-natural amino acids than any other solution in each run

full coverage

Full coverage of available chemical space: 10 to the power of 30 possible solutions

WE ADVANCE DRUG INNOVATION ON 2 FRONTS

Collaborations

In House Development

SEVERAL PROJECTS IN DISCOVERY STAGE

PUBLICATIONS & PATENTS

22 Oct, 2018

Computationally Designed Bispecific MD2/CD14 Binding Peptides Show TLR4 Agonist Activity

15 Dec, 2017

From Finance to Molecular Modelling Algorithms: The risk and Return Heuristic

21 Jul, 2015

Structural basis of glycogen branching enzyme

MANAGEMENT TEAM

Immanuel Lerner

CEO, Co-founder | PhD Path 2 Copy 29Created with Sketch.
Scientist and Biotech entrepreneur with a proven track record in envisioning and establishing a successful AI/biotech startup. Co-Invented, founded and currently leading Pepticom. Led Pepticom from concept to revenue generation via collaboration with large multinational companies, negotiated and executed multiple discovery deals and seed/Round A finance. A Merage Institute Business Executive Leadership Program alumni. Immanuel’s 15 year academic career Prior to the establishment of Pepticom includes a Ph.D. in biochemistry followed by postdoctoral from the Hebrew University of Jerusalem. During his studies he published his research in leading journals such as Blood, Nature communications, The Journal of clinical investigation, Cancer research and others (with the honor of publishing his postdoc research with the 2017 Nobel laureate in Physiology/Medicine Prof. Michael Rosbash).

AMIT MICHAELI

CTO, Co-founder | PhD, MBA Path 2 Copy 29Created with Sketch.
Dr. Michaeli developed Pepticom’s core technology and has extensive algorithm development experience in both the chemical and financial fields. In is Ph.D. research conducted at the Hebrew University in Jerusalem, Dr. Michaeli developed characterization of peptide and protein design and specialized in design optimization algorithms. In addition to a doctorate, he holds an M.Sc. in Human Genetics and a Master’s in Business Administration (MBA), majoring in Finance.

MAAYAN ELIAS

SVP Business Development & Marketing PhD, MBA, BSc. Pharm Path 2 Copy 29Created with Sketch.
Dr. Elias Robicsek has 12 years of experience in the pharmacy field as a trained pharmacist. She earned her Ph.D. from the Hebrew University in the computational chemistry field of Chemoinformatics models aimed at identifying possible interaction of developed drugs with Cytochrome P450. Dr. Elias Robicsek also holds an MBA, majoring in Finance, general and strategic management.

SHAUL MEZAN

Chief Biologist | PhD Path 2 Copy 29Created with Sketch.
Dr. Mezan has over 13 years of research experience, mainly in the fields of cancer cell biology and molecular neurobiology. Before earning his PhD from the Hebrew University for research of brain RNA metabolism and circadian rhythms, Dr. Mezan was part of BioCanCell’s R&D team for four years. Dr. Mezan manages Pepticom’s research laboratory at the Hebrew University campus and parts of Pepticom’s biological activity done with the Company’s collaborators.

Shoshi Keynan

VP Business Development | PhD Path 2 Copy 29Created with Sketch.
Dr. Keynan holds a Ph.D. in biochemistry from the Hebrew University, Faculty of Medicine and spent four years as a postdoctoral fellow in the biochemistry and molecular biology department at Leeds University, UK. Dr. Keynan brings 20 years’ experience in the health and biotech industry with a unique perspective on research and development and also in business development and startup incubation. In the last 11 years she was responsible for managing Yissum's healthcare portfolio of new technologies and inventions, signing on numerus license and collaboration agreements.

BOARD OF DIRECTORS

Mrs. Hamburger is a member of the board since 2014. Mrs. Hamburger is a knowledgeable business-woman with 20 years of experience in senior managerial positions and is an investor in various Biomed companies. Mrs. Hamburger has a broad background in financial and operational disciplines.

Founder and Chairman of the Chartered Group which comprises of dozens of portfolio companies globally located in Japan, Singapore, Germany, Thailand, Luxembourg and IsraelMr. Agmoni graduated from New York University Stern School of Business (NYU Stern), London School of Economics and Political Science (LSE) and HEC School of Management, Paris (HEC Paris), with three MBA diplomas granted from each school.

Chartered Group is actively involved with numerous private equity transactions investing in Japan and the Southeast Asian region. In recent years, the Group increased its exposure to investment in high-tech deals in Israel. Since its inception in 2003, Chartered Group successfully brokered and invested in deals exceeding US$ 2Bn to finance both public and private companies.

Mrs. Kut is an accomplished adviser, passionate investor and Stanford grad with 30+ years of technical and financial experience managing large Hi-Tech projects and teams at companies including NDS/Cisco, Algorithmics, Frame Technology and IntelliCorp. 

Scientist and Biotech entrepreneur with a proven track record in envisioning and establishing a successful AI/biotech startup. Co-Invented, founded and currently leading Pepticom. Led Pepticom from concept to revenue generation via collaboration with large multinational companies, negotiated and executed multiple discovery deals and seed/Round A finance. A Merage Institute Business Executive Leadership Program alumni.

Immanuel’s 15 year academic career Prior to the establishment of Pepticom includes a Ph.D. in biochemistry followed by postdoctoral from the Hebrew University of Jerusalem.
During his studies he published his research in leading journals such as Blood, Nature communications, The Journal of clinical investigation, Cancer research and others (with the honor of publishing his postdoc research with the 2017 Nobel laureate in Physiology/Medicine Prof. Michael Rosbash).

Scientific Advisory Board

Neely Ivgy-May, Ph.D. is a Pharmaceutical Drug Development Leader specializing in CNS, Women’s Health, and Uro-Oncology. Dr. Ivgy-May provides scientific and clinical expertise to Commercial Development and Business Development. She has a vast experience in interacting with the FDA and other regulatory authorities (EMA, PMDA) as clinical lead during pre-IND, End of Phase II, and pre- NDA meetings; Advisory Committee planning and participation. Dr. Ivgy-May is the founder and CEO of Ivgy-May Consulting Services. She worked close to 20 years in leading companies of the pharmaceutical industry: Schering Plough, Organon International and Merck Inc. Dr. Ivgy-May holds Masters and Doctor of Philosophy degrees from Columbia University College of Physician & Surgeons New York, NY.

David S. Siegel, M.D., Ph.D., specializes in Hematology & Oncology and is Chief of Division for Multiple Myeloma (MM) at John Theurer Cancer Center at Hackensack University Medical Center (UMC). Dr. Siegel is one of the foremost authorities on Multiple Myeloma in the U.S.; he serves as a lead investigator in multi-center clinical trials for MM and led to the FDA’s fast-track approval of Kyprolis (carfilzomib) for relapsed Multiple Myeloma patients. Dr. Siegel’s research has been published in many leading medical journals, including Nature, New England Journal of Medicine, Blood and Journal of Clinical Oncology. He is a member of the Multiple Myeloma Research Consortium (MMRC) Steering Committee.

Jonathan E. Cohen M.D., Ph.D. specializes in Cancer Research and Neuroscience at Hadassah – Hebrew University Medical Center. In his clinical work, Dr. Cohen focuses on General Oncology, while establishing his unique clinic of Malignant Melanoma and Cancer Immunotherapy with the objective of leveraging and extending novel therapies based on the Immune system for Melanoma, as well as for other solid tumors. Dr. Cohen is a co-investigator on several multi-center clinical trials and presented his work at international conferences and in peer reviewed journals.

Professor Anwar Rayan is a co-Founder of Pepticom. Prof. Rayan is an expert in the field of Bioinformatics, Chemoinformatics, drug design and discovery. During his work at the School of Pharmacy at the Hebrew University in Jerusalem and at FMP in Berlin, Prof. Rayan gained vast experience in the field of drug discovery and the development of algorithms. He contributed to the development of novel tools for protein/peptide structure prediction, protein-protein docking, drug- likeness and Molecular Bioactivity Indexing. Dr. Rayan is a Research Associate at the Hebrew University of Jerusalem and a Researcher at the QRC – Qasemi Research Center, Alkasemi College. He holds a B.Sc. in Chemistry with distinction and earned a Ph.D. in Medicinal Chemistry from the Hebrew University of Jerusalem.

Dr. Rivière has over 25 years of biopharmaceutical industry experience with R&D leadership roles in target and drug discovery, nonclinical and early-stage clinical development. He is a recognized expert in peptide therapeutics with both established peptide modalities and emerging novel peptide technologies. Dr. Rivière is Founder and CEO of Peptide Logic, a San Diego-based biotech company developing novel peptide therapeutic modalities. He previously was CSO at CovX, a leading peptide-antibody conjugates company; a SVP of Pfizer worldwide R&D and member of the Pfizer Leadership Team; and SVP Research at Ferring Pharmaceuticals, a leading peptide therapeutics company. He is also a co-founder of Cara Therapeutics and of the Peptide Therapeutics Foundation and the Annual Peptide Therapeutics Symposium. Dr. Rivière received a PhD in animal physiology and biology from the Institut National Polytechnique, Toulouse, and completed postdoctoral studies at the University of Arizona, Tucson.

Dr. Waleed Danho held the position of Distinguished Research Leader at Hoffmann-La Roche Inc. in Nutley, New Jersey, USA. until 2011. He is a reviewer for the Journal of Peptide Research, QSAR & Combinatorial Science and the Journal of Medicinal Chemistry; he is a member of the editorial board of The International Journal of Peptide Research and Therapeutics. Dr. Danho authored and co-authored over 250 scientific articles and 21 patents in the field of peptides. He has presented and chaired various sections of the American, European and International Peptide Symposia since 1972. He is a council member of the American peptide society (2011-presentresent). In January of this year, Dr. Danho joined Tory Pine Institute for Molecular Study (TPIMS) as an Adjunct member. In March 2012 Dr. Danho was appointed to the board of trustees of the Boulder Peptide Society.

In 2009, Dr. Danho was awarded the” Lifetime Achievement Award” from the North Jersey section of the American Chemical Society. Last September, Dr. Danho also was awarded the “2009 Meienhofer Award” at Roche Colorado Corporation Peptide Symposium “RCCPS 09”.